Officials say more than 1.4 million of Gaza's civilian population of about 2.3 million have been made homeless.
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Gaza: Israel said its forces fought Hamas gunmen inside the militants' vast tunnel network beneath Gaza as a hospital director said more than 50 Palestinians were killed in an Israeli air strike on a refugee camp in the besieged enclave.
As the battle inside the tiny Hamas-ruled Palestinian territory intensified, Israeli Prime Minister Benjamin Netanyahu dismissed international calls for a halt to the fighting.
But U.N. and other aid officials warned that a public health catastrophe was engulfing civilians in Gaza, with hospitals struggling to cope with mounting casualties and food, medicine, drinking water and fuel running short.
The director of Gaza's Indonesian Hospital told Al Jazeera that more than 50 Palestinians were killed and 150 wounded in Israeli air strikes on a densely populated area of the Jabalia refugee camp in northern Gaza.
There was no immediate comment from the Israeli military.
The tunnels under the cramped enclave are a prime objective for Israel as it expands a four-day-old ground offensive - after three weeks of aerial bombardment - into Gaza from the north to hit Hamas in retaliation for the Islamist group's deadly surprise attack into southern Israel on Oct. 7.
Some of the 240 hostages that Israel says were seized by Hamas that day are believed to be held in the tunnel complex, adding a further complication for the Israelis on top of the difficulties of fighting in an urban setting.
"Over the last day, combined IDF (Israel Defence Forces) struck approximately 300 targets, including anti-tank missile and rocket launch posts below shafts, as well as military compounds inside underground tunnels belonging to the Hamas terrorist organization," an Israeli military statement said.
Militants responded with anti-tank missiles and machine gun fire, it said. A number of militants were killed, it said, without specifying a number.
Hamas said in a statement its fighters were engaging in fierce battles with Israeli ground forces, who were taking losses. "The occupation is pushing its soldiers into proud Gaza, which will always be the cemetery of invaders," Hamas said.
Israeli forces also bombed the narrow coastal enclave overnight in air, sea and ground attacks, hitting northwestern areas, witnesses said on Tuesday.
Israeli soldiers hit Gaza City, the northern heart of the Gaza Strip, from two directions on Monday, focusing on the key north-south thoroughfare.
Gaza health authorities say that 8,525 people, including 3,542 children, have been killed in Israeli attacks since Oct. 7. U.N. officials say more than 1.4 million of Gaza's civilian population of about 2.3 million have been made homeless.
About 1,400 people, mainly civilians, were killed in the cross-border Hamas assault on Oct. 7, Israel says.
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