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Anti-obesity drug helps people shed 24 kg in clinical trial 

The drug maker claimed that the new drug Tirzepatide has enabled people with obesity or who are overweight to lose about 22.5% of their body weight

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Anti-obesity drug helps people shed 24 kg in clinical trial 
GNN Media: Representational Photo

People with obesity lost at least 24 kilograms on average when they were treated with the highest dose of a new hunger-blocking drug in a large clinical trial. 

The drug named Tirzepatide, developed by American pharmaceutical company Eli Lilly and Company (Lilly), is a once-weekly injection that promotes weight loss by mimicking the effects of natural hormones called incretins. 

As per reports, these hormones lower blood sugar after we eat, in addition to regulating metabolic processes related to digestion.

The drug maker claimed that Tirzepatide has enabled folks with obesity or who are overweight to lose about 22.5% of their body weight. 

The clinical trial enrolled a total of 2,539 participants from across the US, Argentina, Brazil, China, India, Japan, Mexico, Russia and Taiwan. 

On average, participants in the study weighed 105 kg at the outset and had a body mass index (BMI) of 38.

At the end of the study, those taking the higher doses of tirzepatide weighed about 81 kg and had a BMI just below 30. 

Earlier in June 2021, the US Food and Drug Administration approved another obesity drug called semaglutide, which contains a GLP-1 mimic on its own, without the addition of Gastric inhibitory polypeptide (GIP). 

Semaglutide also promotes weight loss, but by about 15% on average, suggesting that the added GIP component in tirzepatide gives an extra boost. 

Like semaglutide, tirzepatide can trigger side effects such as nausea, vomiting, diarrhoea and constipation that seem worse at higher doses.

The only other treatment is bariatric surgery, which can result in substantial weight loss. But many people are ineligible or simply do not want the surgery. 

It is pertinent to mention here that the company is yet to submit the data for publication in a peer-reviewed medical journal or presented them in a public setting, the claims nonetheless amazed medical experts. 

World

Morocco: 27 migrants die in stampede to enter Spain’s Melilla

The incident at the border crossing was the first since Spain and Morocco boosted their bilateral cooperation after Madrid decided to support Rabat’s position on the independence of Western Sahara. 

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Morocco: 27 migrants die in stampede to enter Spain’s Melilla

Moroccan authorities said that 27 migrants were killed and dozens of migrants and police officers were injured in a “stampede” of people trying to cross into the Spanish North African enclave of Melilla.

According to the Moroccan Association for Human Rights (AMDH), the death toll of migrants who died trying to cross from Morocco into the Spanish enclave of Melilla rose to 27 today (June 25). 

On Friday, around 2,000 migrants—many from Sudan—tried to cross the militarized border fence.

At first, five people were reported dead, but later, Moroccan authorities raised the figure to 18. 

“The victims of the tragedy in Melilla agonized for hours under the cruel gaze of those who were supposed to help them and did not do so,” tweeted founder of Walking Borders Helena Maleno Garzon, who also confirmed the report of 27 dead.

Spanish officials said 49 Civil Guards sustained minor injuries while four police vehicles were damaged by rocks thrown by some migrants. 

Videos from the Moroccan side of the border show what appear to be dead bodies and people with severe injuries strewn out on the ground without receiving medical attention. 

Other images show hundreds of people, some with clear injuries, lying in a pile on the ground with their hands tied behind their backs.

Moroccan police used tear gas to disperse those trying to climb the border fence.

Following the horrific incident, several NGOs are calling for an immediate investigation into the treatment of migrants. 

The incident at the border crossing was the first since Spain and Morocco boosted their bilateral cooperation after Madrid decided to support Rabat’s position on the independence of Western Sahara. 

Spanish Prime Minister Pedro Sanchez on Friday applauded the “extraordinary work of the Moroccan government in coordination with Spain to try to stop a violent assault, which was, in this case, well resolved.”

Last year, Moroccan authorities stood passively by as thousands swam into the Spanish enclave of Ceuta amid a diplomatic spat over Spain treating the separatist leader of Western Sahara for coronavirus.

According to Spanish authorities, just 133 people managed to reach Spain during Friday’s border crossing attempt. 

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World

Int’l Day in support of Victims of Torture being observed today

The day serves as a reminder to people that torture is a crime

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Int’l Day in support of Victims of Torture being observed today

Islamabad: Intentional Day in support of Victims of Torture is being observed today across the globe including Pakistan to remind people that human torture is not only unacceptable but it is also a crime.

International Day in Support of Victims of Torture is an international observance held annually on 26 June to speak out against the crime of torture and to honour and support the hundreds of thousands victims and survivors across the world.

On June 26, 1987, the convention against torture came into force. It was an important step in the process of globalizing human rights and acknowledging that torture and inhuman or degrading treatment or punishment should be universally illegal. In 1997 the United Nations General Assembly decided to mark this historic date and designated June 26 each year as the international day in support of victims of torture.

The first International Day in Support of Victims of Torture was held on June 26, 1998. It was a day when the United Nations appealed to all governments and members of civil society to take action to defeat torture and torturers everywhere.

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Business

AJK govt presents Rs 163.7 billion budget

The development budget has been increased by Rs. 2 billion as compared to the previous financial year.

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AJK govt presents Rs 163.7 billion budget

Mirpur: The government of Azad Jammu & Kashmir Saturday presented its maiden budget with an estimated outlay of Rs.163.7 billion for the next financial year 2022-23.

In the budget, an amount of Rs.135.2 billion has been allocated for recurring expenditure whereas a chunk of Rs. 28.5 billion has been allocated for development expenditure.

The development budget has been increased by Rs. 2 billion as compared to the previous financial year.

The budget proposes a 15 percent Disparity Reduction Allowance, an increase in the revised pay scale, and a 15 percent increase for pensioners.

The development budget includes Rs1.8 billion for public health, Rs 2.17 billion for education, and 12 billion for communication.

Presenting the budget for the financial year 2022-23 in the Azad Jammu Kashmir Legislative Assembly which met in the State metropolis on Saturday, the AJK Finance Minister Abdul Majid Khan said that the total expenditure for the next financial year has been estimated at Rs 135.20 billion.

He said that total development expenditure was estimated at Rs 28.50 billion.

Moreover, the minister said that an amount of 500 million has been proposed in terms of foreign aid.

Revised budget for the financial year 2021-22, amounting to 135.7 billion was also presented in the legislative assembly.

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